Compound prepared from chalcone catalyzed by monovalent iodine reagent as well as preparation method and application of compound

• Main Authors: LIANG ZHIQIN, ZHENG MEIQIONG, XIA HAIDONG, HUANG CHAO, DUAN YANAN
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a compound prepared by catalyzing chalcone with a monovalent iodine reagent, which has a structural formula shown in a general formula (A) or a general formula (B), and a preparation method of the compound comprises the following steps: by taking a chalcone compound shown in a general formula (1) or a general formula (2) as a raw material, uniformly mixing the raw material with the iodine reagent, mCPBA and acid in an organic solvent by taking the iodine reagent as a catalyst; and stirring and reacting for 12-72 hours at room temperature, and purifying by column chromatography to obtain the compound with the general formula (A) or the general formula (B). In the preparation method, a catalytic amount of monovalent iodine reagent is used, so that the whole experiment process is greener. 本申请涉及一价碘试剂催化查尔酮制备的化合物，具有通式(A)或通式(B)的结构式，其制备方法包括：以具有通式(1)或具有通式(2)的查尔酮类化合物为原料，在有机溶剂中，以碘试剂作为催化剂，将原料与碘试剂、mCPBA和酸均匀混合，室温条件下搅拌反应12-72小时，经柱层析纯化可得到具有通式(A)或具有通式(B)的化合物。制备方法使用了催化量的一价碘试剂，使整个实验过程会更加绿色。