Novel longlikaurin A derivative as well as preparation method and medical application thereof

• Main Authors: DU PIAN, XU SHENGTAO, XUE SONGTAO, HE CHEN, YAO HONG, LIU JUNKAI, XU JINYI
• Format: Patent
• Language: Chinese; English
• Published: 22.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a novel longlikaurin A analogue and derivative as well as a preparation method and medical application of the novel longlikaurin A analogue and derivative, and the structure of the novel longlikaurin A C-14-site hydroxyl derivative is shown as a formula I; the invention also discloses a preparation method of the novel compounds and application of the novel compounds in the field of tumor disease treatment. 本发明公开一种新型的长栲利素A类似物及衍生物、其制备方法及医药用途，新型长栲利素A的C-14位羟基衍生物，结构如式I所示；本发明还公开了这些新型化合物的制备方法以及其在治疗肿瘤疾病领域的应用。