Mifepristone capsule and preparation method thereof

• Main Authors: WU FAQING, JIANG HAIBING, QIU WEN, LING XIANGPING
• Format: Patent
• Language: Chinese; English
• Published: 22.04.2022
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention discloses a mifepristone capsule and a preparation method thereof. The mifepristone capsule comprises mifepristone, a solubilizer, an adhesive, an acidity regulator and a diluent. The preparation method of the mifepristone capsule comprises the following steps: firstly crushing mifepristone, and then mixing the crushed mifepristone with a solubilizer to obtain a mifepristone mixture containing the solubilizer; mixing the mifepristone mixture containing the solubilizer with an adhesive, an acidity regulator and a diluent to obtain a capsule content; and finally, filling the capsule content into an empty capsule to obtain the mifepristone capsule. The mifepristone capsule prepared by adding the self-made solubilizer has a very good slow-release effect in intestinal tracts, and the bioavailability can be remarkably improved. 本发明公开了一种米非司酮胶囊及其制备方法，其包括米非司酮，增溶剂，黏附剂，酸度调节剂，稀释剂。该米非司酮胶囊的制备方法为先将米非司酮粉碎，再将粉碎后的米非司酮与增溶剂混合，得到含有增溶剂的米非司酮混合物；再将含有增溶剂的米非司酮混合物与黏附剂、酸度调节剂、稀释剂混合得到胶囊内容物；最后将胶囊内容物灌装进空胶囊得到米非司酮胶囊。本发明通过添加自制的增溶