Method for determining acetate in sodium ozagrel raw material medicine

• Main Authors: FAN ZHAOZE, HU WEI, HU RENJUN, SU LILIN, YU YANPING, GONG DANFENG, CHEN CHENG
• Format: Patent
• Language: Chinese; English
• Published: 19.04.2022
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a method for determining acetate in a sodium ozagrel raw material medicine. The determination method comprises the following step: detecting by adopting an ion chromatography method, wherein the chromatographic conditions are as follows: the chromatographic column is Thermo Dionex IonPac AS19, the column temperature is 20-30 DEG C, and the column temperature is 20-30 DEG C; the mobile phase is a KOH solution; the gradient elution is divided into three steps: the first step is that the KOH concentration is maintained to be 8-12 mmol/L within 0-(7-12) min; in the second step, the KOH concentration is maintained to be 30 mmol/L within the time from (7.1-12.1) min to (12-20) min; and in the third step, the concentration of KOH is maintained to be 8-12 mmol/L within the time range from (12.1-20.1) min to (14-30) min. According to the determination method disclosed by the invention, the content of acetate in sodium ozagrel can be accurately detected under given conditions. 本发明公开了一种奥扎格雷钠原料药中乙