Methods and compositions relating to TERT activation therapy

• Main Authors: SHIM HONG-SEOK, HORNER JAMES W, DE PINHO, RONALD, A, WANG YAOQI
• Format: Patent
• Language: Chinese; English
• Published: 15.04.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure provides methods and compositions for the treatment of premature senility disorder or nervous system degenerative diseases, particularly nervous system degenerative diseases associated with amyloid deposition and neuronal death, such as Alzheimer's disease. Accordingly, aspects of the present disclosure relate to methods for treating premature senility in a subject in need thereof, comprising administering to the subject a TERT activation therapy. Other aspects relate to methods for treating a nervous system degenerative disease in a subject comprising administering to the subject a TERT activation therapy. 本公开内容提供了用于治疗早衰症或神经系统变性疾病，特别是与淀粉样蛋白沉积和神经元死亡相关的神经系统变性疾病，例如阿尔茨海默病的方法和组合物。因此，本公开的方面涉及用于治疗有需要的对象的早衰症的方法，其包括向对象施用TERT激活疗法。其他方面涉及用于治疗对象的神经系统变性疾病的方法，其包括向对象施用TERT激活疗法。