Application of food-borne bone soup nanoparticles

• Main Authors: GAO GUANZHEN, ZHOU JIANWU, KE LIJING, YU ZHAOSHUO, RAO PINGFAN, WANG HUIQIN
• Format: Patent
• Language: Chinese; English
• Published: 15.04.2022
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; NEW BREEDS OF ANIMALS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

The invention relates to the field of biological medicine, in particular to application of food-borne bone soup nanoparticles, food-borne bone soup nanoparticle components are obtained from pig bone soup through gel filtration chromatography separation and purification, and inflammation expression is inhibited by reducing generation of inflammatory factors IL1beta, IL-6 and TNF-alpha, so that the food-borne bone soup nanoparticles have a good application prospect. The food-borne bone soup nanoparticles can protect mouse ulcerative colitis induced by DSS and regulate intestinal flora disorder caused by colitis, and in the process of establishing an ulcerative colitis mouse influence model, it is found that the food-borne bone soup nanoparticles can effectively increase the body weight and colon length of the mouse with colitis, improve the hematochezia condition and the fecal form of the mouse with colitis and improve the intestinal flora disorder of the mouse with colitis. The compound can improve the colon p