NLRP3 inhibitors

• Main Authors: VAN WILTENBURG JIMMY, DEN HARTOG, JACOBUS, A., J, MACLEOD ANDREW, SHANNON JONATHAN, MILLER DAVID, CASTAGNA DAVID, CARRILLO ARREGUI JOKIN
• Format: Patent
• Language: Chinese; English
• Published: 08.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to substituted 5-membered nitrogen-containing heteroaryl compounds, such as triazole esters, in which the heteroaryl ring is further substituted by a linking group, such as-NH-, with a cyclic group, which in turn is alpha-substituted. The invention further relates to related salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical conditions and diseases, most particularly in the treatment and prevention of medical conditions and diseases by NLRP3 inhibition. 本发明涉及取代的5元含氮杂芳基化合物，诸如三唑酯，其中所述杂芳基环通过诸如-NH-的连接基团被环状基团进一步取代，所述环状基团继而为α位取代的。本发明进一步涉及相关盐、溶剂化物、前药和药物组合物，并且涉及此类化合物在治疗和预防医学病症和疾病中的用途，最尤其是在通过NLRP3抑制来治疗和预防医学病症和疾病中的用途。