Triazole derivative or pharmaceutically acceptable salt thereof as well as preparation method and application thereof

• Main Authors: WANG XIAONA, WU XIONGZHI, LI YALONG, SU XIAOXUAN, OU TIANMIAO, LI KUNTAO, SUN JIAYU, CHEN YUERU, ZOU JING
• Format: Patent
• Language: Chinese; English
• Published: 08.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a triazole derivative or a pharmaceutically acceptable salt thereof as well as a preparation method and application thereof. The structural formula of the triazole derivative or the pharmaceutically acceptable salt thereof is shown as a formula (I) or a formula (II). The triazole derivative or the pharmaceutically acceptable salt thereof provided by the invention has an AUF1 protein targeting effect, can trigger oncogene translation disorder, and has a better anti-tumor effect. The triazole derivative can be applied to preparation of antitumor drugs. 本发明提供了一种三唑类衍生物或其药学上可接受的盐及其制备方法和应用。其三唑类衍生物或其药学上可接受的盐的结构式如式(Ⅰ)或式(Ⅱ)所示：本发明提供的三唑类衍生物或其药学上可接受的盐具有靶向AUF1蛋白的作用，并能够引发癌基因翻译紊乱，具有较好的抗肿瘤效果。该三唑类衍生物可以在制备抗肿瘤药物中应用。