2-pyrazole-3-benzimidazole derivative as well as preparation method and application thereof

• Main Authors: HU QINGHUA, LI HUANQIU, ZHU YIFAN, ZHOU MENGZE, WANG HUI, WEI RUONAN
• Format: Patent
• Language: Chinese; English
• Published: 05.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a 2-pyrazole-3-benzimidazole derivative as well as a preparation method and application thereof. The 2-pyrazole-3-benzimidazole derivative has a structure as shown in a formula I which is described in the specification. Experimental results show that the 2-pyrazole-3-benzimidazole derivative provided by the invention has relatively good P2Y6 receptor antagonistic activity and in-vitro anti-inflammatory activity, and can be applied to preparation of drugs for treating inflammatory diseases related to P2Y6 receptors. 本发明提供的2-吡唑-3-苯并咪唑衍生物及其制备方法和应用，2-吡唑-3-苯并咪唑衍生物具有式Ⅰ所示结构。实验结果表明，本发明提供的2-吡唑-3-苯并咪唑衍生物具有较好的P2Y6受体拮抗活性和体外抗炎活性，可以作为制备P2Y6受体相关炎症性疾病治疗药物的应用。