Extracellular vesicles derived from activated CAR-T cells

• Main Authors: GLOBERSON LEVIN ANAT, HORN, GAVIN, AHARON ARIE, ESHHAR ZEEV, AVIVI ITSHAK, WACHS TILO
• Format: Patent
• Language: Chinese; English
• Published: 01.04.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides extracellular vesicles (EVs) derived from T cells expressing chimeric antigen receptors (CARs) that are specifically activated with antigens that specifically bind to the CAR, pharmaceutical compositions comprising these vesicles, and their use in the treatment of cancer. In particular, the present invention illustrates EVs derived from activated T cells expressing CARs that specifically bind to HER2 cancer antigens, pharmaceutical compositions comprising these EVs, and their use in the treatment of cancers that overexpress HER2, such as ovarian cancer and breast cancer. 本发明提供了源自表达嵌合抗原受体(CAR)的T细胞的细胞外囊泡(EV)、包含这些囊泡的药物组合物以及它们在治疗癌症中的用途，所述T细胞是用CAR特异性结合的抗原特异性活化的。特别地，本发明举例说明了源自活化T细胞的EV、包含这些EV的药物组合物以及它们在治疗过度表达HER2的癌症(例如卵巢癌和乳腺癌)中的用途，所述活化T细胞表达特异性结合HER2癌抗原的CAR。