Cobalt ferrite nanoparticles, and preparation method and application thereof

• Main Authors: HE YAN, LI HAIHONG, HWANG JUN-HO, CHEN JINGMAN, LIANG YUANTING, LIU XUJIE, LI YUSHAN, WANG YAKUN, ZHANG KUN, CHEN NIPING
• Format: Patent
• Language: Chinese; English
• Published: 01.04.2022
• Subjects: CHEMISTRY; COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSESC01D OR C01F; HUMAN NECESSITIES; HYGIENE; INORGANIC CHEMISTRY; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention belongs to the technical field of nano-drugs, and particularly discloses cobalt ferrite nano-particles as well as a preparation method and application thereof. According to the technical scheme, cobalt ferrite (CoFe2O4) nanoparticles are prepared through a high-temperature reaction by taking metal cobalt salt, metal ferric salt and sodium acetate as precursors, an organic alcohol solution as a solvent and a polyethylene glycol derivative mPEG-P (AGE-MPA) as a stabilizer; the CoFe2O4 nanoparticles prepared by the preparation method disclosed by the invention are good in stability, small in particle size, free of obvious cytotoxicity and high in biological safety, have excellent photo-thermal performance and Fenton reaction performance of tumor microenvironment response, and can be used as an anti-tumor nano-drug. According to the CoFe2O4 nano-drug, the synergistic effect of a photothermal therapy and a chemical kinetic therapy is realized, the CoFe2O4 nano-drug has a more obvious tumor treatment