Infusion cell freezing medium and application thereof

• Main Authors: TAN WENSONG, HUANG HUIMIN, CAI HAIBO, SHI XIAODI
• Format: Patent
• Language: Chinese; English
• Published: 01.04.2022
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The invention provides an infusion cell cryopreservation solution. The infusion cell cryopreservation solution comprises the following components in percentage by volume: 10% of glycerol; 20% of a human serum albumin injection; and the balance of hydroxyethyl starch 40 sodium chloride injection. Wherein the human serum albumin injection contains human serum albumin with the mass ratio of 20%; the hydroxyethyl starch 40 sodium chloride injection comprises 60g/L of hydroxyethyl starch 40 and 9g/L of sodium chloride. The cell freezing medium capable of being infused does not contain dimethyl sulfoxide, clinical adverse reactions caused by dimethyl sulfoxide in a traditional cell freezing medium are avoided, and efficient, safe and stable cell freezing is achieved; in addition, the cell cryopreservation liquid capable of being infused can be used for clinical-grade cryopreservation of CAR-NK cells and can be directly infused after resuscitation. 本申请提供一种可输注细胞冻存液，其按体积百分比包含：甘油10％；人血白蛋白注射液20％；以及余量为羟乙基淀粉40氯化钠注射液；其中，所述