Synthesis method of electrochemical oxidation beta-thiocyano substituted alkenyl amide compound

• Main Authors: GU QINGYUN, ZENG XIAOBAO, CHENG ZHENFENG
• Format: Patent
• Language: Chinese; English
• Published: 22.03.2022
• Subjects: APPARATUS THEREFOR; CHEMISTRY; ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTIONOF COMPOUNDS OR NON-METALS; METALLURGY

The invention relates to the technical field of organic synthesis, in particular to a synthesis method of an electrochemical oxidation beta-thiocyano substituted alkenyl amide compound, which comprises the following steps: A, sequentially adding a compound 1, a compound 2, an electrolyte and a solvent into a reactor equipped with an electrode plate; b, carrying out stirring reaction on the compound 1 and the compound 2 under the conditions of certain temperature and constant current under an open condition; c, after the reaction is finished, decompressing and evaporating to remove the solvent to obtain a crude product; and D, carrying out column chromatography purification to obtain the beta-thiocyano substituted alkenyl amide compound 3. Compared with the traditional synthesis method, the method has the advantages that the reaction condition is mild, and the reaction can be smoothly carried out at room temperature; the operation is simple, and all operations can be carried out in an open system; current is u