Preparation method of 2, 4-diaminopyrimidine oxide

• Main Authors: TENG XIN, JIAN YIMIN, TAN CHANG, ZHANG HAOQIAN, LI TENG
• Format: Patent
• Language: Chinese; English
• Published: 22.03.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; SPIRITS; VINEGAR; WINE

The invention relates to the technical field of synthesis of heterocyclic compounds, and particularly discloses a preparation method of a 2, 4-diaminopyrimidine oxide. The preparation method comprises the following step: carrying out cyclization reaction on 3-oxopropionitrile and guanidine under an oxidation condition to generate the 2, 4-diaminopyrimidine oxide. Wherein the 3-oxopropionitrile is obtained by oxidizing a medicinal chemical 3-hydroxypropionitrile which is low in price and easy to obtain and is used as a raw material. The reaction is green and mild, and synthesis of the imenius molecules from simple, cheap and easily available raw materials is realized. 本发明涉及杂环化合物的合成技术领域，具体公开了一种2,4-二氨基嘧啶氧化物的制备方法。所述制备方法包括以下步骤：由3-氧代丙腈和胍在氧化条件下进行环合反应生成2,4-二氨基嘧啶氧化物。其中，3-氧代丙腈由廉价易得的医药化学品3-羟基丙腈为原料，经氧化后得到。本发明的反应绿色温和，实现从简单、价廉、易得的原料出发合成亚美尼斯分子。