Method for synthesizing aryl nitrile compound from tert-butyl isonitrile

• Main Authors: ZHANG ZHIGUO, LIU YUNKUI, JIN HONGWEI, ZHOU BINGWEI
• Format: Patent
• Language: Chinese; English
• Published: 22.03.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a synthesis method of an organic compound, in particular to a method for synthesizing a nitrile substance under the action of nickel by using tert-butyl isocyanate as a cyanation reagent, and the method is characterized in that an iodobenzene compound as shown in a formula I and tert-butyl isocyanide as shown in a formula II are used as raw materials to obtain a nitrile compound as shown in a formula III. The nickel bromide is rich in reserve and low in price, the reaction cost is reduced, the toxicity of the used tert-butyl isocyanide is low, the production difficulty is reduced, and the life safety of production personnel is protected. The method provided by the invention can effectively synthesize various aryl nitrile compounds. 本发明涉及一种有机化合物的合成方法，具体地说涉及一种使用叔丁基异氰酸酯作为氰基化试剂，在镍的作用下合成腈类物质的方法，该方法以式Ⅰ所示的碘代苯类化合物和式Ⅱ所示的叔丁基异腈为原料，得到式Ⅲ所示的腈类化合物。本发明所述的溴化镍储量丰富、价格低廉，降低了反应成本，使用的叔丁基异腈毒性较低，降低生产难度，保护了生产人员的生命安全。本发明所述方法能有效合成各类芳基腈类化合物。