P2X7 receptor targeted therapy

• Main Authors: LESHI ELMIRA, LALA ROMAIN, GILBERT SIMON, MCNULTY SEAN, OLIPHANT CHRIS
• Format: Patent
• Language: Chinese; English
• Published: 11.03.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to methods of treating cancer, in particular cancer that is resistant to chemotherapeutic agents. In particular, the present invention relates to a method of treating cancer in an individual that is not responsive or no longer responsive to chemotherapy, the method comprising the steps of: providing an individual that is not responsive or no longer responsive to a chemotherapeutic agent; providing in an individual a complete antibody or a fragment thereof comprising a variable domain for binding to the P2X7 receptor expressed by the individual; wherein the P2X7 receptor is impaired in response to ATP such that it cannot form apoptosis pores under normal physiological conditions. 本发明涉及治疗癌症，特别是对化学治疗剂产生抗性的癌症的方法。特别地，本发明涉及在不响应于或不再响应于化学治疗的个体中治疗癌症的方法，所述方法包括以下从而在个体中治疗癌症：提供不响应于或不再响应于化学治疗剂的个体；在个体中提供完整抗体或其包含用于与该个体表达的P2X7受体结合的可变结构域的片段；其中所述P2X7受体对ATP的响应受损，使得其在正常生理条件下不能形成凋亡孔。