PDL1 positive NK cell cancer therapy

• Main Authors: YU JIANHUA, DONG WENJUAN, CALIGIURI MICHAEL A
• Format: Patent
• Language: Chinese; English
• Published: 11.03.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are methods of treating cancer in a subject comprising detecting the amount of PD-L1 (+) natural killer (NK) cells in a biological sample from the subject, and treating the subject with an anti-cancer therapy. Provided herein are methods of treating cancer in a patient comprising isolating natural killer (NK) cells from a subject, generating a population of PD-L1 (+) NK cells from the isolated NK cells, and administering the population of PD-L1 (+) NK cells to the patient. 本文提供了治疗受试者的癌症的方法，所述方法包括检测来自所述受试者的生物样本中PD-L1(+)自然杀伤（NK）细胞的量，以及用抗癌疗法治疗所述受试者。本文提供了治疗患者的癌症的方法，所述方法包括从受试者中分离出自然杀伤（NK）细胞，从所述分离的NK细胞中产生PD-L1(+)NK细胞群，以及将所述PD-L1(+)NK细胞群施用给所述患者。