Antibacterial hemostatic composite dressing and preparation method thereof

• Main Authors: LIU LEI, WANG FENGHUA, SUN JIAHUA
• Format: Patent
• Language: Chinese; English
• Published: 11.03.2022
• Subjects: BRAIDING; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; COTTON-WOOL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS,NON-WOVEN FABRICS; HUMAN NECESSITIES; HYGIENE; KNITTING; LACE-MAKING; MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARYMATERIAL; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; NON-WOVEN FABRICS; TEXTILES; TRIMMINGS; WADDING

The invention belongs to the field of medical materials, and discloses an antibacterial hemostatic dressing and a preparation method thereof. The composite dressing comprises a substrate layer and a nanofiber modification layer, the substrate layer is a chitosan spunlace non-woven fabric, the nanofiber modification layer is an alkylated chitosan/acidified carbon nanofiber/polyvinyl alcohol nanofiber film, the nanofiber modification layer material is modified on the chitosan spunlace non-woven fabric of the substrate layer in an electrostatic spinning mode, and the chitosan spunlace non-woven fabric is prepared. The composite dressing with the antibacterial and hemostatic functions is prepared. The substrate layer of the prepared composite dressing can rapidly coagulate blood, and the nanofiber modification layer can kill bacteria, reduce excessive loss of blood and promote blood coagulation. The substrate layer and the nanofiber modification layer cooperate to coagulate, and the coagulation cascade reaction i