Component composition based on traditional Chinese medicine and application thereof in treating depression

• Main Authors: ZHAO XUE, ZHAO XINFENG, DENG YUQING, WANG SIWANG
• Format: Patent
• Language: Chinese; English
• Published: 04.03.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a traditional Chinese medicine-based component composition and an application thereof in treating depression. The composition comprises the following active ingredients in parts by weight: 1.0-3.0 parts of magnoflorine, 0.8-1.0 part of crocin I and 0.8-1.0 part of butylphthalide. According to the invention, the active components in the Ligusticum wallichii-cape jasmine and spina date seed-Ligusticum wallichii medicine pairs are defined, and are compounded to obtain the pharmaceutical composition with excellent efficacy, clear components and no obvious toxic or side effect, and the pharmaceutical composition is expected to be developed as a novel medicine for improving and/or treating depression and anxiety disorder. 本发明涉及一种基于中药的成分组合物及其治疗抑郁症的应用，所述组合物包含木兰花碱1.0-3.0份、西红花苷I 0.8-1.0份、丁苯酞0.8-1.0份作为有效成分。本发明明确了"川芎-栀子"和"酸枣仁-川芎"药对中的活性成分，并对活性成分进行复配，得到了药效优异、成分明确、无明显毒副作用的药物组合物，有望开发作为新型改善和/或治疗抑郁症、焦虑症的药物。