Method for evaluating and screening drug properties and meridian-inducing components of a traditional Chinese medicine meridian-inducing drug

• Main Authors: XIA YONGGANG, LIANG JUN, ZHANG YI, CHAI YANQUN
• Format: Patent
• Language: Chinese; English
• Published: 22.02.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The invention discloses a method for evaluating and screening drug properties and meridian-inducing components of a traditional Chinese medicine meridian-inducing drug. The endoplasmic reticulum-Golgi apparatus transport system traditional Chinese medicine channel-inducing drug property evaluation method is constructed by combining the aspects of cell viability after drug administration, endoplasmic reticulum-Golgi apparatus activation, endoplasmic reticulum stress, related protein expression, material transport and the like. The constructed endoplasmic reticulum-Golgi apparatus transport system traditional Chinese medicine channel-inducing drug property evaluation method is adopted to perform comprehensive analysis on channel-inducing drug property splitting components of a traditional Chinese medicine platycodon grandiflorum, and it is determined that a platycodon grandiflorum supernatant component is a channel-inducing drug property active component of the platycodon grandiflorum. The traditional Chinese m