Substituted heteroaryl compound and composition and application thereof

The invention provides a substituted heteroaryl compound and a composition and application thereof. The compound is a compound represented by a formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound repres...

Full description

Saved in:
Bibliographic Details
Main Authors XU WANGJIN, CHEN SHUYING, XI NING, LI MINXIONG, CHEN PENG, CHEN WUHONG, BAI CHANGLIN, WANG BIN
Format Patent
LanguageChinese
English
Published 22.02.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention provides a substituted heteroaryl compound and a composition and application thereof. The compound is a compound represented by a formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound represented by the formula (I). The invention also provides a pharmaceutical composition containing the compound, and the compound and the pharmaceutical composition can regulate the activity of JAK kinase, especially the activity of TYK2, and are used for preventing, handling, treating and alleviating diseases or disorders mediated by the activity of the JAK kinase. 本发明提供了一类取代的杂芳基化合物及其组合物和用途。其中，所述的化合物为式(I)所示的化合物或者式(I)所示化合物的立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药。本发明还提供了包含所述化合物的药物组合物，所述的化合物和药物组合物可以调节JAK激酶的活性，尤其是TYK2的活性，用于预防、处理、治疗和减轻JAK激酶活性介导的疾病或紊乱。
Bibliography:Application Number: CN202110923343