Aryl formamide compound as well as preparation method and medical application thereof

• Main Authors: ZHANG SHOULIANG, CHEN BIN, YIN HUIJUN, ZONG LIBIN, LIU GUOBIAO, YAN XU
• Format: Patent
• Language: Chinese; English
• Published: 18.02.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to an arylformamide compound as well as a preparation method and medical application thereof. Particularly, the invention relates to a compound as shown in a general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound and application of the compound as a P2X3 receptor antagonist, and the compound and the pharmaceutical composition containing the compound can be used for treating and/or preventing diseases related to P2X3 activity, for example, chronic cough, pain, endometriosis, overactive bladder and the like, wherein the definition of each substituent group in the general formula (I) is the same as that in the specification. 本发明涉及芳甲酰胺类化合物及其制备方法和医药用途。特别地，本发明涉及通式(I)所示的化合物、其制备方法及含有该化合物的药物组合物，及其作为P2X3受体拮抗剂的用途，该化合物及含有该化合物的药物组合物可以用于治疗和/或预防与P2X3活性相关的疾病，例如慢性咳嗽、疼痛、子宫内膜异位、膀胱过度活动症等。其中通式(I)中的各取代基的定义与说明书中的定义相同。