Synthetic method of symmetric spiro-dinaphthalene natural product and analogue of symmetric spiro-dinaphthalene natural product

• Main Authors: DENG JUN, LONG XIANWEN
• Format: Patent
• Language: Chinese; English
• Published: 18.02.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthetic method of a symmetric spiro-dinaphthalene natural product and an analogue thereof. The synthetic method specifically comprises the following three methods: (1) preparing a compound 3 from a compound 1; (2) sequentially preparing a compound 4, a compound 5 and a compound 6 from the compound 1; and (3) sequentially preparing a compound 7, a compound 8, a compound 9 and a compound 10 from the compound 1. The synthesis method disclosed by the invention is simple, efficient and economical, the synthesis of the novel symmetric spiro-dinaphthalene natural product sprioaxillarone A and the analogues thereof can be quickly completed, and the preparation of more than gram level is realized. 本发明公开了一种对称螺环双萘天然产物及其类似物的合成方法，具体包括以下三种的方法：①由化合物1制备得到化合物3；②由化合物1依次制备得到化合物4、化合物5、化合物6；③由化合物1依次制备得到化合物7、化合物8、化合物9、化合物10。本发明合成方法简单、高效、经济，能够快速的完成新型对称螺环双萘天然产物sprioaxillarone A及其类似物的合成，实现克级以上数量的制备。