Method for manufacturing phosphine compound

• Main Authors: J.M. THORPE, R.P. TOOZE, G.R. EASTHAM
• Format: Patent
• Language: Chinese; English
• Published: 03.03.2004
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

通式(R#-[3]-C)#-[2]P-L#+[1]-X-L#+[2]-P-(C-R#-[3])#-[2]的化合物(I)的制备方法，其中各个R独立地为与叔碳原子C相连的可任选被取代的侧有机基团；L#+[1]、L#+[2]独立地为连接各磷原子与X基的选自可任选被取代的低级亚烷基链的连接基，以及X为桥连基，该桥连基包括可任选被取代的芳基部分，并且所述磷原子在可用的相邻碳原子上与之相连，包括以下步骤：(i)使式A-L#+[1]-X-L#+[2]-A的化合物(II)与金属M在适合的溶剂中一起反应生成式A-M-L#+[1]-X-L#+[2]-M-A的中间化合物(III)，其中A为卤原子；(ii)使所述中间化合物(III)与式(R#+[3]-C)#-[2]P-A#+[1]的化合物(IV)反应生成所述化合物(I)，其中A#+[1]为卤原子，并且可与A相同或不同。所述化合物(I)可用于形成烯烃羰基化作用的催化剂体系。 A method of preparing a compound (I) of general formula (R3-C)2P-L1-X-L2-P-(C-R3)2, in which R is independently a pendant, optionally substituted, organic group through which the group is linked to tertiary carbon atoms C; L1 and L2 are independently, a linking group selected from an optionally substituted lower alkylene chain connecting the respective phosphorous atom to the group X, and X is a bridging group comprising an optionally substituted aryl moiety to which the phosphorous atoms are linked on available adjacent carbon atoms; comprising: (i) reacting together a compound (II) of formula A-L1-X-L2-A, in which A is a halogen atom, with a metal M in a suitable solvent or form an intermediate compound (III) of formula: A-M-L1-X-L2-M-A; (ii) reacting said intermediate compound (III) with a compound (IV) of formula: (R3-C)2P-A1, wherein A1 is a halogen atom which may be the same as or different from A, to form said compound (I).