METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES

• Main Authors: SHIRAKI NOBUAKI, KUME SHOEN, KIHO TOSHIHIRO, YANO TATSUYA
• Format: Patent
• Language: Chinese; English
• Published: 11.02.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided is, as a means for efficiently inducing the differentiation of a pluripotent stem cell into an insulin-producing cell, a method comprising a step for three-dimensionally culturing a cell in a medium containing dihydroindolizinone derivatives. 作为有效地诱导多能干细胞分化成胰岛素生产细胞的手段，提供包含用含有二氢吲嗪酮衍生物的培养基将细胞进行三维培养的步骤的方法。