Rhodanine fluorescent probe compound for detecting fluorine ions and preparation method of rhodanine fluorescent probe compound

• Main Authors: YUE YI, LIU SHENGPU, YAN LONGJIA, ZOU YING, LIU LI
• Format: Patent
• Language: Chinese; English
• Published: 08.02.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; ADHESIVES; CHEMISTRY; DYES; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; PHYSICS; POLISHES; TESTING

The invention discloses a rhodanine fluorescent probe compound for detecting fluorine ions and a preparation method of the rhodanine fluorescent probe compound. The structural formula of the rhodanine fluorescent probe compound is shown in the specification. The preparation method comprises the following steps of: carrying out a substitution reaction on 2-methoxyl-10H-phenothiazine and iodopropane to generate 2-methoxyl-10-propyl-10H-phenothiazine (a compound 2); carrying out a formylation reaction on the compound 2, DMF (Dimethyl Formamide) and phosphorus oxychloride to generate 2-methoxy-10-propyl-10H-phenothiazine-3-formaldehyde (a compound 3); hydrolyzing the compound 3 to generate 2-hydroxy-10-propyl-10H-phenothiazine-3-formaldehyde (a compound 4); carrying out a substitution reaction on the compound 4 and tert-butyldimethylsilyl chloride to obtain 2-((tert-butyldimethylsilyl) oxy)-10-propyl-10H-phenothiazine-3-formaldehyde (a compound 5); and reacting the compound 5 with 3-ethyl-2-thiothiazolidine-4-ket