Method for removing pyrogen in alginate dressing

• Main Authors: SONG GUOLIANG, XIE ZEPING, LI CHENGBO, GONG SHIZHOU, QU CHENGLEI, WANG CHAO, SHEN SHENGBIAO, ZHANG SHUMIN
• Format: Patent
• Language: Chinese; English
• Published: 25.01.2022
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

The invention provides a method for removing a pyrogen in alginate dressing, and relates to the technical field of biomedical materials. The method comprises the steps of performing soaking with a 0.1 mol/L sodium hydroxide solution for 4 hours to remove the pyrogen (endotoxin); and removing residual alkali liquor and impurities by using pyrogen -free raw water or weak acid water to realize the aim of removing the pyrogen. The process flow and operation are simple, large-scale application is facilitated, the problem that the pyrogen in existing alginate dressing products is unqualified is solved, and the safety of products is further guaranteed. 本发明提供了一种去除海藻酸盐敷料中热原的方法，涉及到生物医用材料的技术领域。本发明采用0.1mol/L的氢氧化钠溶液浸泡4h来去除热原(内毒素)；然后用无热原水或弱酸水洗去残留的碱液及杂质，实现其除热原的目的。本发明工艺流程及操作简单，便于规模化应用，解决了现有海藻酸盐敷料类产品中热原不合格的问题，进一步保证了产品的安全性。