Preparation method and application of nano preparation hydrogel

• Main Authors: TONG RONGSHENG, CHEN XINMIAN, YANG LEI, CAI LULU, TAN SUMIN
• Format: Patent
• Language: Chinese; English
• Published: 21.01.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention discloses a preparation method and application of nano preparation hydrogel, and relates to the field of antitumor drugs. The gambogic acid micelle hydrogel disclosed by the invention is prepared by mixing gambogic acid micelles and a hydrogel solution, the gambogic acid micelle hydrogel is in a solution state at room temperature and is in a gel state at body temperature; the gambogic acid micelle hydrogel has good biocompatibility and good biological safety, can slowly release gambogic acid in vivo, is easy for in-situ injection and convenient for clinical application, and has a remarkable anti-tumor effect. 本发明公开了一种纳米制剂水凝胶的制备方法和应用，涉及抗肿瘤药物领域。本发明公开的藤黄酸胶束水凝胶由藤黄酸胶束与水凝胶溶液混合制成；该藤黄酸胶束水凝胶在室温呈现溶液状态，在体温呈凝胶状态；生物相容性良好，在体内可缓控释放藤黄酸，具有较好的生物安全性，易于原位注射，便于临床应用，具有显著的抗肿瘤作用。