Double-drug-loaded nanofiber hydrogel composite cartilage repair system and preparation method thereof

• Main Authors: WEN JING, LI KEBI, ZHU CHENYUE, XU PEIHU, REN SHUYI, XU MIN, HUANG ZHIJUN, LI YUNHUI, YUE YUNQING, XU JINGYI, XU HAIXING, WANG ZIYI, LI YANGYI
• Format: Patent
• Language: Chinese; English
• Published: 18.01.2022
• Subjects: APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS; BRAIDING; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS; COTTON-WOOL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS,NON-WOVEN FABRICS; HUMAN NECESSITIES; HYGIENE; KNITTING; LACE-MAKING; MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARYMATERIAL; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OFARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES ORRIBBONS; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; NATURAL OR ARTIFICIAL THREADS OR FIBRES; NON-WOVEN FABRICS; SPINNING; TEXTILES; TRIMMINGS; WADDING

The invention discloses a double-drug-loaded nanofiber hydrogel composite cartilage repair system. Kartogenin-loaded coaxial nanofibers are used as a skeleton, and gaps of the skeleton are filled with sodium aescinate-loaded composite hydrogel, so that an elastic cylinder is finally formed, wherein the coaxial nanofibers consist of a core layer and a shell layer, the core layer is polylactic acid, the kartogenin is uniformly dispersed in the polylactic acid, and the shell layer is silk fibroin; the composite hydrogel consists of sodium aescinate, chitosan and oxidized hydroxyethyl cellulose, and the sodium aescinate is uniformly dispersed in the chitosan. The double-drug-loaded nanofiber hydrogel composite cartilage repair system has excellent biocompatibility and mechanical properties, a coaxial fiber membrane can provide correct guidance for cartilage regeneration, and meanwhile, double-drug-loaded gradient release can promote cartilage repair in different stages, so that the quality of cartilage repair is