Warfarin-4-O-acetyl-Gly-Pro-Arg-Pro-AA1 as well as synthesis, activity and application thereof

• Main Authors: HOU MENGYU, ZHANG XIAOYI, ZHAO MING, PENG SHIQI
• Format: Patent
• Language: Chinese; English
• Published: 14.01.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses four kinds of warfarin-4-O-acetyl-Gly-Pro-Arg-Pro-AA compounds, a preparation method of the compounds, an advantage of the compounds without bleeding side effects, an antagonistic effect of the compounds on a blood coagulation factor II, and an antagonistic effect of the compounds on a tissue factor/blood coagulation factor VII, and discloses the venous thrombosis resisting effect of the compounds. 本发明公开了4种华法林-4-O-乙酰-Gly-Pro-Arg-Pro-AA化合物,公开了它们的制备方法,公开了它们无出血副作用的优点,公开了它们对凝血因子II的拮抗作用,公开了它们对组织因子/凝血因子VII的拮抗作用,公开了它们的抗静脉血栓作用。