Preparation method of aliphatic asymmetric thiourea compound

• Main Authors: SONG SHIJIE, WANG ZONGHAO, ZI SHOUYUN, YUAN YANAN, ZHANG XUXU, FU SHUNGUO, YANG RUICHAO, ZHANG ZHILIANG, ZHAO XIAOFENG, HOU WANXI, ZHANG YAN, LIU JIE, SHEN ZHIQIANG, WANG FANGXIAO, CHANG SHUAIJUN
• Format: Patent
• Language: Chinese; English
• Published: 14.01.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; COMPOSITIONS BASED THEREON; METALLURGY; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS

The invention discloses a preparation method of an aliphatic asymmetric thiourea compound, which specifically comprises the following steps of: adding a secondary amine compound into water or without a medium, and slowly adding carbon disulfide for reaction to obtain a dithiocarbamic acid intermediate; and slowly adding a primary amine compound into the system, mixing for reaction, heating for reaction, and removing hydrogen sulfide to obtain the aliphatic thiourea compound product. No organic solvent is used in the reaction, the yield is high, the operation is simple, separation and purification are easy, and the method is a synthesis route suitable for industrialization. 本发明公开了一种脂肪族不对称硫脲类化合物的制备方法，具体过程如下：将仲胺类化合物加入水中或无需介质，再将二硫化碳缓慢加入反应得到二硫代氨基甲酸中间体；再将伯胺类化合物缓慢加入体系中，混合反应，再升温反应，脱去硫化氢，得到脂肪族不对成硫脲类化合物产品。反应不使用有机溶剂，产率高，操作简单，易于分离纯化，是一条适合工业化的合成路线。