Elagolix freeze-dried tablets and preparation method thereof

• Main Authors: WANG ZHANGQUAN, LIU ZHIPENG, LI XIE, ZHU LEI, CHEN LIN, JIA YUANCHAO
• Format: Patent
• Language: Chinese; English
• Published: 04.01.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses elagolix freeze-dried tablets. The elagolix freeze-dried tablets comprise an active ingredient elagolix, an excipient, an adhesive, a pH regulator, a taste masking agent, a flavoring agent and a solvent, and comprises the following components in parts by weight: 200 parts of active component elagolix, 30-50 parts of excipient, 20-50 parts of adhesive, 5-20 parts of pH regulator, 1-5 parts of taste masking agent, 10-40 parts of flavoring agent and 800-900 parts of solvent. The invention further discloses a preparation method of the elagolix freeze-dried tablets. The elagolix freeze-dried tablets and the preparation method thereof have the following advantages: no dust is generated in the production process, and the environmental pollution is less; the prepared products are smaller in tablet weight and adopt fewer auxiliary materials; the freeze-dried tablets are low in water content and stable in quality, and impurities are hardly increased in the storage process; in the clinical using