LIPID CONJUGATE PREPARED FROM SCAFFOLD MOIETY

The application relates to a lipid conjugate of formula M-X1-L wherein M is a molecule of interest such as a drug moiety; X1 is a linker group such as ester, ether or carbamate; and L is a lipid scaffold represented by formula (lId): -L1-[L2(H)(X2R)]n-L3-[L4(H)(X2R)]p-L5-L6 and wherein L comprises 5...

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Bibliographic Details
Main Authors TAM YUEN YI, CIUFOLINI MARCO, ZAIFMAN JOSHUA, CHEN SAM
Format Patent
LanguageChinese
English
Published 28.12.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The application relates to a lipid conjugate of formula M-X1-L wherein M is a molecule of interest such as a drug moiety; X1 is a linker group such as ester, ether or carbamate; and L is a lipid scaffold represented by formula (lId): -L1-[L2(H)(X2R)]n-L3-[L4(H)(X2R)]p-L5-L6 and wherein L comprises 5 to 40 carbon atoms and 0 to 2 carbon-carbon double bonds. The lipid conjugate can be formulated in a drug delivery vehicle such as a lipid nanoparticle (LNP). 本申请涉及式M-X1-L的脂质缀合物，其中M是关注的分子，例如药物部分；X1是连接基，例如酯、醚或氨基甲酸酯；且L是由式(IId)表示的脂质支架：-L1-[L2(H)(X2R)]n-L3-[L4(H)(X2R)]p-L5-L6，并且其中L包含5-40个碳原子和0-20个碳-碳双键。可以将所述脂质缀合物配制在药物递送载体例如脂质纳米颗粒(LNP)中。
Bibliography:Application Number: CN202080019604