Substituted diazahetero-bicyclic compounds and their use

• Main Authors: GREEN DALES, BECK-BROICHSITTER MORITZ, J. ANRAL, DELBECK MARTINA, MULLER THOMAS, NICOLAI JANINE, LUSTIG KLEMENS, ROSENSTEIN BJORN, COLLINS KARL, HAHN MELANIE, ALBUS UDO, LINDNER NIELS
• Format: Patent
• Language: Chinese; English
• Published: 28.12.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1-and/or TASK-3-blocking properties. 本申请涉及新型(咪唑并[1,2-a]吡啶-3-基)甲基-取代的二氮杂-杂双环化合物、其制备方法、其单独或组合用于治疗和/或预防疾病的用途，及其用于制备用于治疗和/或预防疾病，特别是用于治疗和/或预防呼吸病症，包括睡眠相关的呼吸病症，如阻塞性和中枢性睡眠呼吸暂停和打鼾的药物的用途。本申请还涉及发现具有TASK-1和/或TASK-3阻断性质的化合物的方法。