COMPOSITIONS AND METHODS FOR NUCLEOTIDE MODIFICATION-BASED DEPLETION

• Main Author: GOURGUECHON STEPHANE B
• Format: Patent
• Language: Chinese; English
• Published: 21.12.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Provided herein are compositions and methods for enriching a sample for nucleic acids of interest relative to nucleic acids targeted for depletion, comprising using differences in nucleotide modification between the nucleic acids of interest and the nucleic acids targeted for depletion. 本文提供了用于使样品相对于旨在被耗竭的核酸富集所关注核酸的组合物和方法，所述方法包括使用所述所关注核酸与所述旨在被耗竭的核酸之间的核苷酸修饰的差异。