Preparation method and application of graphene oxide-based nitrilotriacetic acid-cerium complex

• Main Authors: WU LI, JI HAIWEI, KANG XIAOXIA, HU HAOLU
• Format: Patent
• Language: Chinese; English
• Published: 21.12.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a preparation method of a graphene oxide-based nitrilotriacetic acid-cerium complex and application thereof. The preparation method comprises the following steps of firstly, enabling graphene oxide (GO) to react with nitrilotriacetic acid (NTA) for carboxylation, and combining cerium ions (Ce <4+>) to form a nano-composite (GO-NTA-Ce) of graphene oxide and cerium. GO-NTA-Ce is an artificial enzyme with DNase-like activity, and shows high shearing capacity on an important component eDNA in an extracellular matrix of a bacterial envelope. When the GO-NTA-Ce is located at a bacterium-related infection site, the GO-NTA-Ce can inhibit the formation of a biofilm for a long time, and can effectively disperse formed biofilms of different ages. In addition to the DNase-like activity effect mediated by Ce, near-infrared light irradiates GO-NTA-Ce to generate local high heat to kill bacteria protected by a film. Graphene plays an antibacterial role through physical damage and chemical damage. Acc