Compound for nucleic acid liquid-phase synthesis carrier as well as preparation method and application of compound

The invention relates to a compound for a nucleic acid liquid-phase synthesis carrier as well as a preparation method and application of the compound, and particularly discloses a fused ring compound capable of serving as the nucleic acid liquid-phase synthesis carrier. The fused ring compound is sh...

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Bibliographic Details
Main Authors QIN ZHIQI, LI JIN, CHEN XING, FAN GUOSHENG, WAN JINQIAO, WANG XING
Format Patent
LanguageChinese
English
Published 17.12.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention relates to a compound for a nucleic acid liquid-phase synthesis carrier as well as a preparation method and application of the compound, and particularly discloses a fused ring compound capable of serving as the nucleic acid liquid-phase synthesis carrier. The fused ring compound is shown in the a formula I defined in the description, wherein X is selected from O, NH, -(CH2)nO- or a chemical bond, Y is selected from CH or N, and is a single bond or a double bond; the value of m is 1 or 2; and the value of n is 1 or 2. The compound for liquid-phase synthesis carrier is simple to prepare, high in reaction efficiency and reusable. 本发明涉及一种用于核酸液相合成载体的化合物及其制备方法和用途，具体公开了一种可以作为核酸液相合成载体的稠环化合物，其具有如下式I所示，其中，X选自O、NH、-(CH2)nO-或化学键，Y选自CH或N，为单键或者双键；m的取值为1或2；n的取值为1或2。本发明的液相合成载体化合物制备简单，反应效率高，可重复利用。
Bibliography:Application Number: CN202110658317