Function-integrated multi-level skin wound repair stent and preparation method thereof

• Main Authors: NING XUCHAO, WANG YUANFEI, ZHANG XIAOPEI, LIU NA, WU TONG, ZHOU ZIYI, LENG XIANGFENG
• Format: Patent
• Language: Chinese; English
• Published: 17.12.2021
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OFARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES ORRIBBONS; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING; TEXTILES

The invention belongs to the technical field of medical materials, and relates to a function-integrated multi-layer skin wound repair stent and a preparation method thereof. The main structure of the repair stent is a three-layer stent of layer-by-layer deposition, the upper-layer stent is a centripetal-oriented polycaprolactone nanofiber stent loaded with a centripetal-gradient gelatin/epidermal growth factor bioactive coating, the middle-layer stent is a polycaprolactone/berberine nanofiber stent, and the lower-layer stent is a reticular nanofiber stent coated with an acellular dermal matrix. A designed biological material with the gradient structure has good biocompatibility and degradability, especially has the potential of promoting cell ingrowth, has important application in wound repair and regeneration tissue engineering, and provides a new thought for functionalization of nanofibers. 本发明属于医用材料技术领域，涉及一种功能一体化的多层级皮肤创面修复支架及其制备方法，修复支架主体结构为逐层沉积的三层支架，上层支架为负载向心梯度的明胶/表皮生长因子生物活性涂层的具有向心取向的聚己内酯纳米纤维支架，中层为聚己内酯/黄连素