Preparation method and application of radix ranunculi ternati multi-arm phospholactone substance with breast cancer targeting structure

The invention relates to a preparation method and application of a radix ranunculi ternati multi-arm phospholactone substance with a breast cancer targeting structure. The preparation method comprises the following steps of drying, grinding and sieving cleaned radix ranunculi ternati, adding into wa...

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Main Authors SHU YOUJU, XUE DONG, LIU JINQIONG, LYU QING, JIA XIAOHUI, TANG JINGWEN
Format Patent
LanguageChinese
English
Published 17.12.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention relates to a preparation method and application of a radix ranunculi ternati multi-arm phospholactone substance with a breast cancer targeting structure. The preparation method comprises the following steps of drying, grinding and sieving cleaned radix ranunculi ternati, adding into water, carrying out enzymolysis for 3 hours by utilizing cellulose hydrolase under stirring, adding pectinase and papain, carrying out enzymolysis for 2 hours, adding amylase, carrying out enzymolysis for 1 hour, filtering, and adding folic acid, chitosan sodium alginate and a phenylboronic acid solution into the filtrate, stirring and reacting in a water bath kettle at 80-100 DEG C for 10-15 hours, carrying out reduced pressure distillation on the obtained mixed solution for 10 hours, and freeze-drying the obtained liquid to obtain the multi-arm phospholactone substance. The radix ranunculi ternati is used as a raw material, a biological active substance radix ranunculi ternati lactone is obtained by utilizing a bio
AbstractList The invention relates to a preparation method and application of a radix ranunculi ternati multi-arm phospholactone substance with a breast cancer targeting structure. The preparation method comprises the following steps of drying, grinding and sieving cleaned radix ranunculi ternati, adding into water, carrying out enzymolysis for 3 hours by utilizing cellulose hydrolase under stirring, adding pectinase and papain, carrying out enzymolysis for 2 hours, adding amylase, carrying out enzymolysis for 1 hour, filtering, and adding folic acid, chitosan sodium alginate and a phenylboronic acid solution into the filtrate, stirring and reacting in a water bath kettle at 80-100 DEG C for 10-15 hours, carrying out reduced pressure distillation on the obtained mixed solution for 10 hours, and freeze-drying the obtained liquid to obtain the multi-arm phospholactone substance. The radix ranunculi ternati is used as a raw material, a biological active substance radix ranunculi ternati lactone is obtained by utilizing a bio
Author LYU QING
SHU YOUJU
XUE DONG
TANG JINGWEN
LIU JINQIONG
JIA XIAOHUI
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Snippet The invention relates to a preparation method and application of a radix ranunculi ternati multi-arm phospholactone substance with a breast cancer targeting...
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Preparation method and application of radix ranunculi ternati multi-arm phospholactone substance with breast cancer targeting structure
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