ANTI PD-L1 ANTIBODY AND USE THEREOF

• Main Authors: FANG JIANMIN, LI SHENJUN, ZHAO GUORUI, JIANG JING
• Format: Patent
• Language: Chinese; English
• Published: 14.12.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided in the present invention is a PD-L1 immunosuppressant, and specifically provided are a monoclonal antibody capable of targeting PD-L1, and nucleotides, combinations of polynucleotides, expression vectors and combinations of expression vectors encoding the antibody. Also provided in the present invention is a conjugate or pharmaceutical composition containing the above-mentioned anti PD-L1 antibody. Further provided in the present invention is the use of the above-mentioned anti PD-L1 antibody, nucleotides, combinations of polynucleotides, expression vectors, combinations of expression vectors, conjugate or pharmaceutical composition in the preparation of a medicament for treating or preventing cancers. 本发明提供了一种PD-L1免疫抑制剂，具体提供了一种能够靶向PD-L1的单克隆抗体以及编码这些抗体的核苷酸、多核苷酸组合、表达载体以及表达载体组合。本发明还提供了包含上述抗PD-L1抗体的偶联物或者药物组合物。本发明还提供了上述抗PD-L1抗体核苷酸、多核苷酸组合、表达载体、表达载体组合、偶联物或者药物组合物在治疗或预防癌症的药物中的用途。