Refining method and system of medical intermediate

The invention provides a refining method and system of a medical intermediate. The refining method comprises the following steps: S1, pumping acetone, the medical intermediate and an adsorption material into a decoloring tank to obtain a mixture, and stirring and refluxing for decoloring; S2, perfor...

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Bibliographic Details
Main Authors WANG QIANGANG, TAN JIANQUAN, TAN ZHIYUN, YANG ZONGLU
Format Patent
LanguageChinese
English
Published 14.12.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a refining method and system of a medical intermediate. The refining method comprises the following steps: S1, pumping acetone, the medical intermediate and an adsorption material into a decoloring tank to obtain a mixture, and stirring and refluxing for decoloring; S2, performing vacuum filtration on the decolored mixture, and adding the decolored mixture into a concentration kettle; S3, concentrating the mixture in the concentration kettle, then stirring and cooling, and standing until a crystallized product is obtained; and S4, centrifugally washing the crystallized product with acetone for several times, and drying for finishing refining. By adopting the technical scheme, a pharmaceutical intermediate refining production standard operation specification is established, pharmaceutical intermediate refining production operation is standardized, pharmaceutical intermediate refining purity stability is effectively guaranteed, product quality inconsistency is avoided, product quality is
Bibliography:Application Number: CN202110929951