Rivaroxaban microsphere, and preparation method and application thereof

The invention discloses a Rivaroxaban microsphere, and a preparation method and application thereof. The Rivaroxaban microsphere comprises Rivaroxaban and a biodegradable high-molecular polymer carrier, wherein the biodegradable high-molecular polymer carrier is a lactide-glycolide copolymer, polyla...

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Bibliographic Details
Main Authors TAN CHUNLI, XIONG SUBIN
Format Patent
LanguageChinese
English
Published 14.12.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a Rivaroxaban microsphere, and a preparation method and application thereof. The Rivaroxaban microsphere comprises Rivaroxaban and a biodegradable high-molecular polymer carrier, wherein the biodegradable high-molecular polymer carrier is a lactide-glycolide copolymer, polylactide, polyglycolide or polycaprolactone. The Rivaroxaban microsphere is a white or white-like powdery fine particle, is good in roundness and has a uniform particle size, D50 is 50-100 [mu] m, in-vitro slow release time is as long as 45 days or above, microsphere powder is suspended in a dispersed solvent and is subjected to intramuscular injection into the hind leg of an SD rat, the in-vivo drug release time of an animal is as long as 6 weeks, and effective blood concentration is still maintained within 42 days. Therefore, the Rivaroxaban microsphere is expected to be developed into a new Rivaroxaban long-acting slow-release dosage form, the drug effect lasts for several weeks through one-time administration outs
Bibliography:Application Number: CN202111042718