Chimeric membrane vesicle as well as preparation method and application thereof

• Main Authors: XU WENRONG, WU PEIPEI, ZHANG BIN, QIAN HUI, LI LINLI
• Format: Patent
• Language: Chinese; English
• Published: 30.11.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a chimeric membrane vesicle as well as a preparation method and application thereof, and relates to the technical field of biological medicines. Neu-Ex disclosed by the invention comprises the following preparation raw materials: hucMSC-Ex and Neu-NVs, wherein the hucMSC-Ex and the Neu-NVs are subjected to ultrasonic mixing and then are extruded to obtain the Neu-Ex. The Neu-Ex can be stored at minus 80 DEG C for a long time after being subpackaged, is easy to store and use, can be directly used for preventing and treating the cisplatin-induced acute kidney injury, and has a remarkable effect. The Neu-Ex is counted according to particles, the use dosage is convenient to master, and the Neu-Ex can be used for preparing a medicinal preparation for preventing and treating acute kidney injury. 本发明提供了一种嵌合膜囊泡及其制备方法和应用，涉及生物医药技术领域。本发明所述Neu-Ex的制备原料包括hucMSC-Ex和Neu-NVs，将所述hucMSC-Ex和Neu-NVs超声混合后挤压得Neu-Ex。所述Neu-Ex可以分装后于-80℃长期保存，易于储存和使用，Neu-Ex可直接用于顺铂诱导的急性肾损伤预防和治疗，效果显著；而且所述Neu-Ex按照微粒计数，使用剂量便于掌握，可用于制备防