Application of muscone in preparation of medicine for preventing and treating myocardial fibrosis after ischemia reperfusion injury

• Main Authors: WANG XIAOYAN, LIU QIAN, WANG GUANGYAN, LI BAIHONG, ZHUANG RUIJUAN, CAI WENYUAN, TONG XIAO, GU XIN, LIN ZHOU
• Format: Patent
• Language: Chinese; English
• Published: 30.11.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of muscone, and particularly relates to application of muscone in preparation of medicines for preventing and/or treating myocardial fibrosis related diseases after ischemia reperfusion injury. The invention also discloses a product of which the active ingredient is muscone. The product is used for preventing and/or treating myocardial fibrosis after the ischemia reperfusion injury. Compared with a myocardial infarction model group, the left ventricular ejection fraction and the left ventricular diameter shortening rate of 28-day myocardial infarction mice can be improved after muscone treatment. 本发明公开了麝香酮应用，麝香酮在制备预防和/或治疗缺血再灌损伤后心肌纤维化相关疾病的药物中的应用。还公开了一种产品，其活性成分为麝香酮；所述产品的用途为预防和/或治疗缺血再灌损伤后心肌纤维化。与心梗模型组相比，麝香酮处理后可以提高28天心梗小鼠的左心室射血分数及左室内径缩短率。