BIOMIMETIC ARRAY DEVICE AND METHODS OF USING SAME

• Main Authors: BUDHWANI KARIM I, BUDHWANI KHIDR KISHAN K, BUDHWANI BRAHMA MUBARAK K
• Format: Patent
• Language: Chinese; English
• Published: 26.11.2021
• Subjects: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; TESTING; TRANSPORTING

The present disclosure generally pertains to a biomimetic array device and methods of using the device to expose biological samples to an array of fluids. The device includes a cassette and an inlet region, where the cassette comprises at least one microchamber array and at least one microchannel. Each microchamber within a microchamber array has a top interface that is open to the external environment, so that a biological sample placed at the top interface is positioned to draw fluid from the microchambers. The inlet region comprises at least one well and at least one inlet channel, each well in fluid communication with one inlet channel. Fluid deposited into wells flows through each inlet channel and microchannel in fluid communication with each well containing fluid, so that each microchamber within one microchamber array provides an approximately equal volume of fluid to the biological sample. 本公开大体上涉及仿生阵列装置和使用该装置的方法，以将生物样本暴露到成阵列的流体。该装置包括盒和注入区域，其中盒包括至少一个微室阵列以及至少一个微通道。微室阵列内的每个微室具有对外部环境开放的顶部接口，使得放置在顶部接口处的生