Biocompatible organogel matrices for intraoperative preparation of drug delivery depot

• Main Authors: ARMBRUSTER DAVID A, KERR SEAN HAMILTON, FLOREK CHARLES, JULIEN JUNIOR, BIKRAM-LILES MALAVOSKLISH, JAIN SANJAY
• Format: Patent
• Language: Chinese; English
• Published: 26.11.2021
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure is directed to an organogel drug depot for use in delivering an active agent to a surgical site, such as an implant site, for instance an orthopedic implant site. The present disclosure is also directed to an organogel drug depot for use in a non-sterile environment and application to a non-sterile open wound site. In a further embodiment, there is disclosed a system for preparing an organogel drug depot including an organogel matrix comprising an organogelator and a biocompatible organic solvent; an active agent comprising solid particles; a container including at least one wall having an outer surface and defining a volume capable of containing the organogel matrix and active agent solid particles; and a heating component configured to contact the outer surface and supply an amount of heat to the container. 本公开涉及用于将活性剂递送到手术部位，诸如植入物部位，例如骨科植入物部位的有机凝胶药物贮库。本公开还涉及用于非无菌环境中的有机凝胶药物贮库以及对非无菌开放伤口部位的施加。在另外的实施方案中，公开了用于制备有机凝胶药物贮库的系统，该系统包括有机凝胶基质，该有机凝胶基质包含有机凝胶因子和生物相容性有机溶剂；活性剂，该活性剂包含固体颗粒；容器，该容器包括具有外表面