Application of PPAR[gamma] to influence liver cancer by promoting terminal differentiation of MMP9<+> tumor-associated macrophages

• Main Authors: ZHOU GANGQIAO, QUAN CHENG, YANG AIQING, LU YIMING
• Format: Patent
• Language: Chinese; English
• Published: 23.11.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to the field of biological medicine, in particular to application of PPAR gamma to influence liver cancer by promoting terminal differentiation of MMP9 <+> tumor-associated macrophages. Research results show that the proportion of MMP9+ TAMs in liver cancer tissues is increased and is significantly related to poor prognosis of patients; further experimental results show that PPAR gamma promotes deterioration of liver cancer by inducing differentiation of MMP9 + TAMs; after the PPAR gamma is knocked down or knocked out, the proportion of inducing THP1 cells into MMP9 + TAMs is reduced, and after the PPAR gamma is knocked down or knocked out, the proportion of inducing PBMC cells into MMP9 + TAMs is reduced; after THP1 cells of which PPAR gamma is knocked down or knocked out are induced into TAMs, the migration, invasion and tube forming capabilities of liver cancer cells are reduced; and after the PBMC with the PPAR gamma knocked down or knocked out is induced into TAMs, the migration, in