Novel near-infrared two-zone dye capable of resisting solvent quenching as well as preparation method and application of novel near-infrared two-zone dye

• Main Authors: ZHANG LIAO, ZHOU YEKUN, ZHANG YUTAO, LI JUAN, ZHANG YIYAN, ZHU WEIHONG, WU MENGLAN, ZHAO ZIJUN, GUO ZHIQIAN
• Format: Patent
• Language: Chinese; English
• Published: 23.11.2021
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; LAKES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; MORDANTS; NATURAL RESINS; ORGANIC CHEMISTRY; ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; PAINTS; PHYSICS; POLISHES; TESTING

The invention provides a novel near-infrared two-zone dye capable of resisting solvent quenching as well as a preparation method and application of the novel near-infrared two-zone dye, and relates to a novel solvent-quenching-resistant nitrogen heterocyclic ring-containing NIR-II dye. Experiments show that the near-infrared two-zone dye has the characteristics of high water solubility, long wavelength, solvent quenching resistance, excellent light stability, deep penetration depth, protein enhanced fluorescence emission and the like, and blood vessels and livers of the whole body of a mouse can be seen clearly by injecting the near-infrared two-zone dye into the mouse through tail vein injection. In addition, the structure of the dye is easy to modify, various targeting groups and detection groups can be connected, and the application range is wide. The structure of the compound is as shown in formula I. 本发明提供了一种新型抗溶剂猝灭的近红外二区染料、及其制备方法和应用，是一类新型抗溶剂猝灭的含氮杂环的NIR-II染料。实验表明本发明的近红外二区染料具有水溶性优异，波长长，抗溶剂猝灭，光稳定性优良，穿透深度深以