Preparation method of 3-phenoxybromopropane or analogue thereof

• Main Authors: FU RENZHONG, CAO BAOXIN, ZENG XIAOJUN, YANG YANG, BU WENHUI
• Format: Patent
• Language: Chinese; English
• Published: 23.11.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a preparation method of 3-phenoxybromopropane or an analogue thereof, which comprises the following steps: carrying out substitution reaction and addition reaction on cheap and easily available phenol or aromatic phenol and an allyl compound thereof to obtain 3-phenoxybromopropane and the analogue thereof, and in order to avoid inconvenience caused by using gaseous hydrogen bromide, the high-concentration hydrobromic acid is generated in situ by adopting the bromide and the acid to realize the second-step addition reaction, the process operation is simple, the conditions are easy to control, the atom economy is good, and the method conforms to the current green chemical synthesis direction in a low-pollution and zero-emission manner from the aspect of environmental influence; and in the aspect of cost economy, the cost is reduced to a great extent due to direct utilization of olefin. 本发明公开了一种3-苯氧基溴丙烷或其类似物的制备方法，以廉价且易得的苯酚或其芳香酚和烯丙基化合物，经过取代反应和加成反应得到3-苯氧基溴丙烷及其类似物产品，为避免使用气态溴化氢的不便，本发明采用溴化盐和酸原