Dopamine-like anticoagulant material and preparation method thereof

• Main Authors: XU FUJIAN, WANG GUOSHENG, SONG CHANGTONG, LI YANG, DING XUEJIA, ZHANG YUNING, WU YONGZHEN
• Format: Patent
• Language: Chinese; English
• Published: 23.11.2021
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention relates to a dopamine-like anticoagulant material and a preparation method thereof. The technical problems that an existing material is poor in biocompatibility, and activity is reduced due to hydroformylation pretreatment of heparin are solved. The dopamine-like anticoagulant material is provided with a base material and a coating, and the surface of the base material is provided with amino and quinonyl; and the coating is a dopamine-like coating. The invention also provides a preparation method of the dopamine-like anticoagulant material. The method can be applied to the field of preparation of biomedical materials. 本发明涉及一种基于类多巴胺的抗凝血材料及其制备方法，其解决了现有材料生物相容性差、肝素的醛化预处理带来的活性降低的技术问题，本发明提供的基于类多巴胺的抗凝血材料，其设有基材和涂层，所述基材表面具有氨基和醌基；所述涂层为类多巴胺涂层。本发明同时提供了其制备方法。本发明可用于生物医用材料的制备领域。